ProteinHistorian: Tools for the Comparative Analysis of Eukaryote Protein Origin

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ProteinHistorian: Tools for the Comparative Analysis of Eukaryote Protein Origin

The evolutionary history of a protein reflects the functional history of its ancestors. Recent phylogenetic studies identified distinct evolutionary signatures that characterize proteins involved in cancer, Mendelian disease, and different ontogenic stages. Despite the potential to yield insight into the cellular functions and interactions of proteins, such comparative phylogenetic analyses are...

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ژورنال

عنوان ژورنال: PLoS Computational Biology

سال: 2012

ISSN: 1553-7358

DOI: 10.1371/journal.pcbi.1002567